THE MEASLES VIRUS can lead to serious disease in children by suppressing their immune systems for up to three years, according to a study published in the journal Science on May 8, 2015. The study provides evidence that measles may throw the body into a much longer-term state of “immune amnesia,” where essential memory cells that protect the body against infectious diseases are partially wiped out. This vulnerability was previously thought to last a month or two.
“We already knew that measles attacks immune memory, and that it was immunosuppressive for a short amount of time. But this paper suggests that immune suppression lasts much longer than previously suspected,” said C. Jessica Metcalf, co-author and assistant professor of ecology and evolutionary biology and public affairs, who is affiliated with Princeton’s Woodrow Wilson School of Public and International Affairs.
The research findings suggest that — apart from the major direct benefits — measles vaccination may also provide indirect immunological protection against other infectious diseases.
The work was funded by the Bill & Melinda Gates Foundation, the Science and Technology Directorate of the Department of Homeland Security, and the Research and Policy for Infectious Disease Dynamics (RAPIDD) Program of the National Institutes of Health’s Fogarty International Center.
–By B. Rose Huber