DRUG DEVELOPMENT OFTEN INVOLVES modifying the chemical structure to get the right combination of properties, such as stability and activity. Working in the laboratory of John Groves, the Hugh Stott Taylor Chair of Chemistry, undergraduate Tova Bergsten and graduate student Xiongyi Huang developed a practical and versatile method for altering molecules that could have wide application in drug synthesis and basic research. The method involves using a manganese catalyst to convert carbon-hydrogen bonds into chemical structures known as azides, which are useful for modifying the properties of drugs.
“Since this was my first long-term lab experience, I learned quite a bit,” Bergsten said. “It was eye-opening to be involved in the experimenting, writing and publishing side of a paper. I plan to continue with scientific research, and what I’ve learned through this experience will definitely be useful for my future work.”
The research, which was supported by the National Science Foundation, was published in the Journal of the American Chemical Society on April 14, 2015.
–By Tien Nguyen